Methotrexate-induced Oral Mucositis
이혜진, 권정승, 최영찬, 안형준,
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이혜진 ( Lee Hye-Jin ) - Yonsei University College of Dentistry Department of Orofacial Pain and Oral Medicine
권정승 ( Kwon Jeong-Seung ) - Yonsei University College of Dentistry Department of Orofacial Pain and Oral Medicine
최영찬 ( Choi Young-Chan ) - Yonsei University College of Dentistry Department of Orofacial Pain and Oral Medicine
안형준 ( Ahn Hyung-Joon ) - Yonsei University College of Dentistry Department of Orofacial Pain and Oral Medicine
KMID : 0355220150400020082
Abstract
Methotrexate (MTX) is a chemotherapeutic agent that is used to treat a host of malignancies. But recently, MTX has also been used as a therapeutic agent for chronic inflammatory disorders such as rheumatoid arthritis, psoriasis, and systemic lupus erythematosus. However, MTX is an antimetabolite that affects rapidly dividing normal cells such as oral mucosal epithelial cells, gastrointestinal epithelial cells, and bone marrow cells?which explains why oral mucositis is often an initial manifestation of MTX toxicity. Because oral lesions are frequently initially presented in dental clinics, dentists should consider the possibility of adverse drug reactions in the differential diagnoses of oral lesions through a meticulous collection of patients’ medical histories. In this report, we examine patients who suffered from oral ulcerative lesions upon diagnosis of MTX-induced oral mucositis. Then, we suggest approaches for the diagnosis and treatment of MTX-induced oral mucositis through a review of literature.
키워드
Folic acid deficiency; Methotrexate; Oral mucositis; Rheumatoid arthritis
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